Detalhe da pesquisa
1.
Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD.
Mol Cell
; 81(4): 767-783.e11, 2021 02 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33333017
2.
Repeat expansions confer WRN dependence in microsatellite-unstable cancers.
Nature
; 586(7828): 292-298, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32999459
3.
The PCNA-associated protein PARI negatively regulates homologous recombination via the inhibition of DNA repair synthesis.
Nucleic Acids Res
; 44(7): 3176-89, 2016 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-26792895
4.
Mechanism of substrate hydrolysis by the human nucleotide pool sanitiser DNPH1.
Nat Commun
; 14(1): 6809, 2023 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-37884503
5.
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints.
Nature
; 444(7119): 633-7, 2006 Nov 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-17136093
6.
Tackling PARP inhibitor resistance.
Trends Cancer
; 7(12): 1102-1118, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34563478
7.
Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors.
Science
; 372(6538): 156-165, 2021 04 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33833118
8.
Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage.
Mol Cell Biol
; 25(9): 3553-62, 2005 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15831461
9.
Unresolved recombination intermediates lead to ultra-fine anaphase bridges, chromosome breaks and aberrations.
Nat Cell Biol
; 20(1): 92-103, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29255170
10.
Keeping homologous recombination in check.
Cell Res
; 26(4): 397-8, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26902288
11.
FBH1 Catalyzes Regression of Stalled Replication Forks.
Cell Rep
; 10(10): 1749-1757, 2015 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-25772361
12.
FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress.
Nat Commun
; 4: 1423, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23361013
13.
CtIP-dependent DNA resection is required for DNA damage checkpoint maintenance but not initiation.
J Cell Biol
; 197(7): 869-76, 2012 Jun 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-22733999
14.
LEDGF (p75) promotes DNA-end resection and homologous recombination.
Nat Struct Mol Biol
; 19(8): 803-10, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22773103
15.
SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation.
J Cell Biol
; 192(1): 43-54, 2011 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-21220508
16.
HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes.
Nat Cell Biol
; 12(1): 80-6; sup pp 1-12, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-20023648
17.
Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities.
J Cell Biol
; 186(5): 655-63, 2009 Sep 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-19736316
18.
Human Xip1 (C2orf13) is a novel regulator of cellular responses to DNA strand breaks.
J Biol Chem
; 282(27): 19638-43, 2007 Jul 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-17507382